Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke
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چکیده
منابع مشابه
Levodopa treatment improves functional recovery after experimental stroke.
BACKGROUND AND PURPOSE Delayed treatment of patients with stroke with levodopa/benserazide contributes to enhanced functional recovery, but the mechanisms involved are poorly understood. The present study was designed to investigate if levodopa/benserazide treatment improves recovery of lost neurological function and contributes to tissue reorganization in the rat brain after stroke. METHODS ...
متن کاملCryostimulation improves recovery from oropharyngeal dysphagia after stroke
INTRODUCTION Stroke is considered one of the most frequent neurological causes of oropharyngeal dysphagia. AIM To determine the effect of cryostimulation on oropharyngeal sensitivity and, subsequently, on the swallowing reaction and premature escape of food in patients with neurogenic dysphagia after stroke. METHODS Clinical and experimental study. The study enrolled 7 adult subjects, 6 ...
متن کاملRecovery after stroke.
One hundred and sixty-two patients were referred to a rehabilitation unit after an acute stroke. The patterns of recovery of overall functional ability, arm function, walking and speech in 92 of 101 survivors have been analysed. In all modalities the majority of recovery occurs within 3 months; although improvement is seen thereafter it does not reach statistical significance. Possible reasons ...
متن کاملEffects of metformin in experimental stroke.
BACKGROUND AND PURPOSE Adenosine 5'-monophosphate-activated protein kinase (AMPK) is an important sensor of energy balance. Stroke-induced AMPK activation is deleterious because both pharmacological inhibition and genetic deletion of AMPK are neuroprotective. Metformin is a known AMPK activator but reduces stroke incidence in clinical populations. We investigated the effect of acute and chronic...
متن کاملVagus Nerve Stimulation During Rehabilitative Training Improves Forelimb Recovery After Chronic Ischemic Stroke in Rats.
BACKGROUND AND OBJECTIVE Stroke is a leading cause of long-term disability. Currently, there are no consistently effective rehabilitative treatments for chronic stroke patients. Our recent studies demonstrate that vagus nerve stimulation (VNS) paired with rehabilitative training improves recovery of function in multiple models of stroke. Here, we evaluated the ability of VNS paired with rehabil...
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ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2014
ISSN: 0953-816X
DOI: 10.1111/ejn.12556